Decentralized Imaging Capture

Captures standardized images of psoriasis lesions using the LegitHealth mobile application during a study to evaluate the efficacy and safety of ACME Pharma for the treatment of subjects with moderate to severe plaque psoriasis.

ℹ️ Study Information

• Study Title: A Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled Study — ACME Pharma
• Investigational Product: ACME Pharma
• Scoring: Automated Psoriasis Area and Severity Index (APASI)
• Images per visit: 11 (7 full-body + 4 close-up)
• Imaging mode: Decentralized (from home)

📱 Decentralised Imaging Capture

Decentralised Imaging Capture

Subjects capture 11 perspectives from home using the LegitHealth app. Silhouette overlays guide correct positioning for each view.

Full-body perspectives — capture screen (7 images)

Close-up perspectives — capture screen (4 images)

Example input photos — full-body perspectives

Head Front

Head Back

Trunk + Arms Front

Trunk + Arms Back

Legs Front

Legs Back

Feet Back

Example input photos — close-up perspectives

Head — close-up

Trunk — close-up

Arms — close-up

Legs — close-up

🖼️ Example of Output

Example of Output

APASI automates each component with dedicated models: erythema (RMAE 0.13, below expert variability), desquamation (RMAE 0.153), induration (RMAE 0.151), and pixel-level BSA segmentation (IoU 0.61).

Output — Lesions segmentation

Head Front

Head Back

Trunk Front

Trunk Back

Arms Front

Arms Back

Legs Front

Legs Back

📊 Example of Data

Example of Data

APASI automates all 16 individual PASI assessments (4 components × 4 regions). The AI replaces subjective BSA estimation with pixel-level segmentation, the largest source of inter-rater variability in manual PASI.

Psoriasis Area and Severity Index

APASI Score: 13.6

Report Information

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Timestamp

3/26/2026, 3:28:42 PM

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Analysis performed in

1.8 seconds

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Status

Not reviewed

Body region	Weight	Erythema	Desquamation	Induration	BSA %	Area score	Region PASI
Head	0.1	2	2	1	30%	2	1.0
Trunk	0.3	3	2	2	15%	2	4.2
Upper extremities	0.2	2	1	2	10%	1	2.0
Lower extremities	0.4	3	3	2	20%	2	6.4

PASI = 1.0 + 4.2 + 2.0 + 6.4 = 13.6

💡 Added Value for the Clinical Trial

Added Value for the Clinical Trial

Beyond scoring, the platform monitors PASI response milestones across visits and triggers automated alerts when a patient first reaches a clinically significant threshold.

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Automatic PASI Response Milestone Detection

The platform automatically calculates PASI 75/90/100 response at each visit and flags patients who reach a milestone for the first time.

Example alert notification

SubjectCV5-ES10001-012

Visit comparisonBaseline → Week 16

Baseline APASI18.4

Week 16 APASI2.8

Improvement84.8% — PASI 75 ✓ PASI 90 ✗

Milestone events are logged automatically and surfaced in the sponsor dashboard, eliminating manual score comparison across visits.